Multiple endocrine neoplasms
An autosomal dominant inherited neoplastic syndrome characterized by the development of various endocrine neoplasms and abnormalities in various anatomic sites. There are four types recognized: type 1 (MEN 1), caused by inactivation of the tumor suppressor gene MEN-1, type 2A (MEN 2A), caused by mutation of the RET gene, type 2B (MEN 2B) also caused by mutation of the RET gene, and type 4 (MEN 4) caused by mutation of the CDKN1B gene. Patients with MEN 1 may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. Patients with MEN 2A develop medullary thyroid carcinomas and may also develop pheochromocytomas and parathyroid gland hyperplasia. Patients with MEN 2B develop medullary thyroid carcinomas and numerous neural defects including neuromas. Patients with MEN 4 develop endocrine neoplasms, particularly in the parathyroid glands, pituitary, and pancreas.
Disease Alternative Name
Top Multiple endocrine neoplasms Doctors on Curofy
Top doctors who continously share their opinions on Multiple endocrine neoplasmsSunshine Hospitals
Internal Medicine Resident
ASRAM
MBBS
Trending Diseases
Trending Cases
Diarrhoea is a leading cause of death in children, with nearly 500,000 young lives lost to diarrhoea each year. Almost all these lives could be saved with a low-cost & widely available treatment - oral rehydration salts (ORS). A new study has revealed that ORS is under-prescribed in India; 50% of children with diarrhea did not receive this lifesaving treatment. There are several popular explanations for the under-prescription of ORS in India. What may be the major reason in your opinion?
Doc Insights4 Likes10 Answers- Login to View the image
M.70yrs. Cough with severe pain right chest. 10 days
Dr. Syam Sundar Patro0 Like8 Answers - Login to View the image
36 years old female complained about painful Lymph nodes on the neck region. *Chief Complaints* Painful & swallon lymph nodes at submandibular region of neck. *History* She was experienced with painful lymph nodes last year. She visited ENT, endoscopy showed grade 1 Tonsillitis & Chronic Pharyngitis. Montex was negative Usg neck showed reactive lymphadenopathy. She got resolved after using Antibiotics and some other medicine last year. Now again same complaints, patient is experiencing. *Vitals* Normal *Physical Examination* Normal apart from lymph nodes.
Dr. Suresh Sankabar0 Like7 Answers - Login to View the image
F.46yrs. Palpitation & DOE 2 years Right chest pain 15 days.
Dr. Syam Sundar Patro0 Like7 Answers - Login to View the image
32 years female, complained that reddish discoloration developed after given Nuerobian Injection at Buttock. *Chief Complaints* No Pain & inflammation No rash *History* She had taken Injection Nuerobian intramuscularly left side buttock. After some time at the Left side of the Gluteus Maximus region developed reddish brown color. This discoloration just below the injection site. Not exactly on Injection site. *Vitals* Normal Vitals *Physical Examination* Normal
Dr. Suresh Sankabar1 Like5 Answers