Langerhans cell histiocytosis

A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001)

Disease Alternative Name

langerhans cell granulomatosis
nos
not otherwise specified
histiocytosis x
lch
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