Harp

Human PTN wild-type allele is located within 12p12.1-p11.2 and is approximately 14 kb in length. This allele, which encodes pleiotrophin protein, plays a role in mitogenesis for endothelial, epithelial, and fibroblast cells and neurite outgrowth. Further, aberrations of the gene result in allelic variants that are implicated in tumor invasion, angiogenesis, and metastasis.

Disease Alternative Name

negf-1
pleiotrophin wt allele
hbgf8
hbnf
pleiotrophin (heparin binding growth factor 8
neurite growth-promoting factor 1) gene
ptn wt allele
negf1
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Concluded Case

A 3 weeks old male brought into the emergency department in a state of shock ,born to gravida 2 mother by normal delivery with a birth weight of 3 kg ,no obvious external congenital anomalies .He was discharged on 3 rd of life in a Satisfac...See More

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Concluded answer

Salt losing CAH. Male child is usually missed because of lack of ambiguity in ext genitalia,but a careful look may disclose hyperpigmentation of scrotum,nipples,and mucosa of lips, BP shd be chkd in any child with shock like presentation, w...


Concluded Case

A term newborn born normal vaginal delivery ,developed fever and seizure on day 1 .initial CBC and HCRP was normal .CSF study showed a lot of RBC, 1. What investigation you do for mother ? 2.how to interpret the CSF 3.what is the diagnosis...See More

(Edited)

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, 4 Answers

Concluded answer

When CSF shows high RBC count and LP was non traumatic then it's Herpes simplex meningoncephalitis . Look carefully for vesicular rash. Repeat CBC for thrombocytopenia CSF PCR for HSV shd be done asap. Start Acyclovir IV ,and other support...


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